Monday, June 29, 2026

New blood test detects 90% of aggressive prostate cancer cases, beating current screenings

From foxnews.com

Researchers say the test could enable earlier detection without unnecessary follow-up procedures


A new test could make it easier to detect high-risk prostate cancer cases earlier.

The blood test, called Stockholm3, is showing promise in clinical trials, beating out the traditional, standard prostate-specific antigen (PSA) test.

In a new study published in the Annals of Internal Medicine, researchers from the Karolinska Institutet in Sweden studied the test’s efficacy in more than 12,000 men — mostly Swedish or European — aged 50 to 74.

All participants were tested with PSA and Stockholm3 and were followed for two years. During the follow-up period, 443 men were diagnosed with aggressive prostate cancer.

Stockholm3 detected 90% of aggressive prostate cancer cases compared to 74% for PSA tests.

Stockholm3 missed "significantly fewer" serious cancer cases than PSA. The number of men incorrectly classified as high-risk was similar across both tests, according to a press release.

Thorgerdur Palsdottir, a researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, wrote in a statement that one of the major challenges in prostate cancer is being able to identify the cases that are "truly dangerous."

"Our results show that Stockholm3 identifies significantly more aggressive cancer cases than PSA without increasing the number of unnecessary follow-ups," she said.

"These results point toward a potential change in how prostate cancer screening can be conducted," the researcher added. "A more precise blood test could enable earlier detection of aggressive disease while reducing the number of unnecessary follow-up examinations and procedures."

"A more precise blood test could enable earlier detection of aggressive disease while reducing the number of unnecessary follow-up examinations and procedures," a researcher commented. (iStock)

Study co-author Hari Vigneswaran, chief medical officer of Stockholm3-maker A3P Biomedical, commented on these "promising" findings in an interview with Fox News Digital.

He confirmed that the PSA has been the standard for prostate cancer screening since the 1990s despite its "well-documented limitations."

"It leads to invasive and costly follow-up testing, contributes to over-diagnosis of non-aggressive cancers and, most importantly, it misses a substantial share of aggressive disease," Vigneswaran said.

When aggressive prostate cancer is found while still confined in the prostate, the five-year survival rate is close to 100%, which highlights the importance of early detection, according to the doctor.

Data from the National Cancer Institute’s SEER database show that metastatic prostate cancer has risen over the past decade, suggesting that "we have not improved early detection of the aggressive, curable disease that screening is meant to catch," Vigneswaran said.

"The goal of screening is to find the cancers that need treatment while they are still curable, without raising the number of men who screen positive but don’t have aggressive disease," he said.

Stockholm3 could reduce the need for unnecessary MRIs and biopsies, according to the researcher.

The findings did have some limitations. Stockholm3 is an investigational device and is not available for sale in the U.S., Vigneswaran noted.

The test estimates a man's risk of aggressive prostate cancer, but a biopsy remains the gold standard for confirming the disease.

The company plans to seek FDA approval to use the test for routine screening and will "generate the evidence needed to support that pathway, including U.S. data," Vigneswaran said.

https://www.foxnews.com/health/new-blood-test-detects-90-aggressive-prostate-cancer-cases-beating-current-screenings 

Sunday, June 28, 2026

‘Smaller doses of exercise are a miracle cure’: 14 expert tips to protect your joints

From theguardian.com

Life is much easier if you look after your hips, knees, elbows and shoulders – especially as you get older. Rheumatologists and orthopaedic surgeons explain how to work out, what to eat and how to talk to your doctor 

Our bodies are incredible machines, but we can take the mechanics for granted until something goes wrong. How can we maintain healthy joints throughout life and avoid surgery? Here, rheumatologists and orthopaedic surgeons give their tips …

Move as much as possible

According to the UK chief medical officers, we should all be getting 150 minutes of moderate-intensity exercise (such as brisk walking or cycling) a week, or 75 minutes of vigorous activity (such as running). However, says Prof Scarlett McNally, a consultant orthopaedic surgeon at East Sussex Healthcare NHS trust, about 27% of adults in England “do less than 30 minutes a week of exercise that gets them out of breath. If you can increase that just a little, it has massive health gains.”

Arthritis – joint pain and stiffness – is likely to reduce as sport and exercise participation increases, says Prof Alister Hart, an orthopaedic surgeon at University College London. “Clearly there are caveats,” he says, pointing out that some football and skiing injuries can increase the risk of arthritis, for example. “But on a population level, the more sport, activity and exercise we do, the less arthritis should happen.”

McNally points out that “change is really difficult for people,” especially if they are already experiencing problems in their joints. Osteoarthritis – the most common type of arthritis, which occurs when the protective cartilage around the bones breaks down – is no longer referred to as ‘wear and tear’, she adds, “because joints are better if you use them. Stay active and build up your muscles.” Through this you can “keep them strong and it can reduce the pain to keep them moving”.

“When patients have a lot of pain in their joints, muscles or tendons, then exercise can be a frightening thing to engage with because it might make the pain worse,” says Dr Elizabeth MacPhie, a consultant rheumatologist in Preston. “We have to support patients to understand how to look after their joints when they have arthritis, not to be fearful of doing exercise, and find the right type of exercise for them.”

There are resources online, such as the website Moving Medicine, which can help you to get started.

Pay attention to aches and pains

Generally, movement is medicine, says Hart. “As an orthopaedic surgeon doing a ward round, you see people recovering from hip fractures. What’s the first thing you do? You say, ‘We need to get you up and moving. It will help you heal your tissues by releasing chemicals that will improve your healing.’”

Try low-intensity movements first, such as stretching or cycling, he says. “Over a few weeks, you’ll realise whether you can do things. If you really can’t do anything, then clearly you need to get help. The red flags are pain waking you at night for many nights and a need for painkillers for more than a week.”

Practise glute bridges

A glute bridge … bend your knees to 90 degrees and push your pelvis to the ceiling. Photograph: Posed by model; Nemanja Mohenski/Getty Images

Hart says that the ultimate exercise is glute bridges: “I tell all of my patients that you can do zero harm with glute bridges, and almost anybody can do them – people who are recovering from fractures, hip replacements and back surgery. When you are lying on your back, bend your knees to 90 degrees and push your pelvis to the ceiling. If you do it with an exercise band across the lower thighs, then you start working your gluteal muscles, and that will help both your hips and your knees.”

… and squats

Squatting is equally crucial. “If you fall over and you can’t get up, you’ll become dependent on others very quickly,” explains McNally, “so the glutes and the thigh muscles are very important.” These can be strengthened through squats. Alternatively, “if you’ve got stairs, going up and down them is really good. I teach people sitting-to-standing exercises, because it builds up the same muscles as a squat.”

Do parkrun


“Impact sports such as running often get a bit of a bad name, with the assumption that they are damaging,” says Hart. “In fact, your skeletal muscles and tendons need impact to keep them healthy. If you go into space as an astronaut, you come back wobbling all over the place, because muscles can’t work: you’ve got osteoporosis just from being in space for a month.”

Hart describes running 5k as a “Goldilocks dose”, meaning not too much or too little. You can even take part by walking, says McNally. A healthy living regime, she says, “has to be a habit; it has to be something people just do, otherwise people don’t do it. That’s why parkrun works.”

“Some people like to do long distances or lots of running,” she says. This is fine so long as your body allows you to do it without injury. It’s worth remembering that “the benefits from exercise stop at an hour a day. Beyond that there aren’t so many benefits. Smaller doses really are a miracle cure.”

If you can’t run, swim

‘Low-impact aerobic activities such as swimming appear to reduce pain.’ Photograph: A Bello/Getty Images

“Some activities which are high impact have historically been seen as bad for joints,” says Dr Matthew Hutchinson, a consultant rheumatologist in London and author of Are You Really the Doctor? “You’ll probably have runners who say the contrary, and they may actually be correct – there isn’t good evidence running will lead to long-term joint problems, unless you get injured. Low-impact aerobic activities such as swimming, however, definitely appear to improve function and reduce pain.”

“If people are experiencing pain in their joints, then getting into the water and doing exercise is always easier,” says MacPhie. “Not just swimming, but walking up and down in the pool or doing gentle stretches in the water is a good way to get going.”

Don’t forget to stretch afterwards

Many of us don’t bother to stretch after a workout. “Don’t make it a big deal,” says Hart. “Even if you do two minutes of stretching, that is better than nothing.” He cautions against pushing yourself too far: “Take your joints through their normal range of motion.”

Make time for strength training

Strength training – weights and resistance work – is “the number one way in which you can prevent arthritis. It is never too early or too late,” says Hart.

Even if you are heading for a knee or hip replacement, strengthening is still a good plan. “I’ve had two hip replacements and for the last one I was a day case because my muscles were super-strong,” says McNally. “I couldn’t rotate my hip – it was horribly painful because of the arthritis – but I could go on my electric bike and cycle for an hour, which kept my muscles going, and that meant I could get out of hospital sooner.”

Preparing for surgery is crucial, says McNally: “The big thing is exercise. Just because it hurts when you stand up from a chair the first time doesn’t mean it is going to keep on hurting. Find something you can do – it is likely to be cycling, static cycling or swimming. Keep your muscles strong and practise balancing on the good leg. If you can balance, then you can get to the toilet and back, and you won’t end up stuck in hospital.”

Conditioning is key

Strength training combined with conditioning – cardiovascular or aerobic activityis essential for avoiding injury, says Hart. “All professional sports people know that, but it’s about feeding it down to us lot who are having a go and trying to live a slightly healthier life.”

He holds the view that “you’ve got all the bendy people in the yoga studios – they don’t need more bending and stretching, they need more strength. And you’ve got all the Muscle Marys in the gym – they need a bit more stretching, conditioning and mobility work. Everyone should swap.”

“The more strength you have in the muscles that surround and support a joint, the less strain is often put on that joint to maintain stability,” adds Hutchinson.

It is not just your joints you need to think about, says McNally. “It’s also your bones. Resistance exercises and weights are proven to keep your bones strong and prevent fractures.”

Eat with your joints in mind

“Try to eat a healthy, non-processed diet, with lots of whole foods, fresh fruit and vegetables,” says Hutchinson. “It is very likely that dysregulation of your gut microbiome has a knock-on effect on the development and the severity of inflammatory arthritis [such as rheumatoid arthritis, where the immune system attacks the tissue around joints] and probably other types of arthritis.” He adds that the evidence is quite poor on what specific kind of diet is best for joints, advising instead to focus on the basics: “Fresh fruit, fresh vegetables, food you cook from scratch … doing those things will help your health across pretty much every domain.”

Vitamin D and K are supplements worth taking, says Hart, “particularly in the UK, in winter; it probably helps every single one of your musculoskeletal tissues.” MacPhie says standard supplements are OK, but the best option is D3 (cholecalciferol) at a dose of 400 IU in the winter.

Cod liver oil is also helpful for joints. “It is rich in omega-3 essential fatty acids, which have some anti-inflammatory properties, although we wouldn’t advise this as a treatment for inflammatory arthritis,” says MacPhie.

As for other supplements that are said to help joints, such as creatine for muscle building and glucosamine and chondroitin supplements for osteoarthritis, the experts were cautious about their use.

Slim down if you need to

If you are overweight, losing weight can reduce the strain on joints, says Hutchinson. “There is also some evidence that excess body fat contributes to driving inflammation, and so there is a lot of interest in the dual role of GLP-1 drugs. I’m not saying everyone should take GLP-1 for their joints, but there is probably the benefit that the reduction in weight reduces strain on the joint and inflammation related to metabolic dysfunction.”

Work on describing your pain

Rheumatologists see a lot of patients with unexplained pain. “Describing pain is very difficult,” says Hutchinson. How can you convey it accurately to your doctor? “Try to keep a diary of when it comes on, what time of day, how long it lasts for. Is the pain located in the joint specifically? Is there anything that makes it better or worse? This can ensure that you have the same level of understanding.”

Quit smoking

“For pretty much any disease I can think of, but certainly for rheumatoid arthritis, don’t smoke,” says Hutchinson, as it worsens the condition. “Rheumatoid arthritis is very strongly associated with smoking and the disease’s severity.”

Be careful what you wear on your feet

Carbon-plated shoes have broken all running world records: “What they are doing is changing biomechanics to get an advantage,” says Hart. The downside to this is: “It changes the forces in your body, and if you haven’t strengthened for it, you may have some other knock-on effects you didn’t expect.” There is concern around the potential for stress fractures. “The amount of data is really small but there’s a change, and that change is good for speed, but it does risk an injury. Barefoot shoes have the same risk. There is no shoe that is ideal to wear all of the time.”

“People shouldn’t need expensive kit to start being active,” says McNally. “Any footwear that is comfortable and affordable is fine.”

https://www.theguardian.com/lifeandstyle/2026/jun/24/exercise-miracle-cure-expert-tips-protect-your-joints

Saturday, June 27, 2026

10 ways to beat brain fog

From restless.co.uk 

Most of us will be familiar with the term ‘brain fog’, which describes the uncomfortable sensation of being unable to think clearly and feeling spaced out

Brain fog can affect memory and cause slower thinking, making everyday activities feel more challenging. It can also involve confusion, fatigue, low motivation, trouble concentrating, and/or feeling emotionally numb.

Some people liken brain fog to wading through thick mud or being caught in a haze, where accessing their thoughts and emotions is more difficult.

There are several reasons why brain fog might occur. And while it can be incredibly frustrating and exhausting, thankfully, there are some things we can do to help improve our thinking and concentration.

With that said, we’ve pulled together a list of 10 ways to beat brain fog.

What causes brain fog?

Brain fog itself isn’t a medical condition. Instead, it’s a symptom of other factors and conditions. Some of the most common reasons for brain fog include…

  • Overworking
  • Other hormonal changes, such as thyroid disorders
  • Food intolerance or sensitivities
  • Metal poisoning
  • Medication or cancer treatments

Sometimes, brain fog may be caused by several interlinking factors. For example, menopause can lead to depression, anxiety, and lack of sleep, which can also cause brain fog.

10 ways to beat brain fog and boost your concentration

If you haven’t been diagnosed with a health condition but feel this may be the reason for your brain fog, it’s important to speak to your GP so they can advise on ways to treat or manage it.

The same goes for medication. It’s worth checking with your doctor if it could be affecting your ability to think clearly, as there may be alternative medications or treatments available.

Other ways to beat brain fog and boost your concentration include…

1. Prioritise sleep

Prioritise sleep

The importance of sleep can’t be overstated. When we’re sleep-deprived, our brain cells struggle to communicate effectively, making it tricky to think clearly, concentrate, solve problems, control our emotions, learn, and process memories.

For example, scientists monitored the brain cells of sleep-deprived people by asking them to categorise a selection of images as quickly as possible. The results showed that their brain cells began to slow as they grew tired, and the task became more challenging.

In a follow-up report, the lead researcher said, “We were fascinated to observe how sleep deprivation dampened brain cell activity. Unlike the usual rapid reaction, the neurons responded slowly, fired more weakly, and their transmissions dragged on longer than usual.”

Research also suggests that our brains do most of their housekeeping while we sleep, such as ridding themselves of toxins and dead cells. Without sufficient rest, these cells can accumulate and become toxic to the brain.

Experts recommend that healthy adults need seven to nine hours of sleep per night. One of the best ways to achieve this is to try to sleep and wake up at the same time every day. It can also help to avoid using electronic devices for at least 30 minutes before bed, as the blue light they emit can interfere with our circadian rhythms and keep us awake.

For more tips on getting good quality sleep, head over to our sleep and fatigue section.

2. Focus on one task at a time

If you’re struggling to concentrate or find the energy to complete tasks, try tackling one thing at a time. Multitasking is linked to scrambled thinking, which can drain our energy, overwhelm us, and make it tricky to focus.

In fact, a UK study found that people who multitask by using different forms of media at once – such as texting while watching TV – have lower grey matter density than those who use one device at a time. Grey matter is a tissue in the brain that’s involved in information processing.

Plus, this study found that participants who multitasked experienced a drop in IQ scores to the average range of an eight-year-old child.

If you struggle to stick to one task at a time and worry about things slipping through the net, it can be helpful to use calendars and create to-do lists. Sometimes, simply ticking things off a list can give us a sense of control and satisfaction, which can boost morale, motivation, and confidence.

3. Work on your memory

Work on your memory

Forgetfulness can be normal with age. But there are ways we can boost our memory and keep it sharp, such as puzzle-solving.

Solving jigsaw puzzles has been shown to improve short-term memory by reinforcing connections between brain cells. Research has also found an association between doing crosswords later in life and a delayed onset of memory decline.

To try some puzzles, check out our articles: 11 free online puzzles and games to tease your brain and 7 health benefits of doing jigsaw puzzles for more information.

Things like relying on road signs or paper maps, rather than GPS, can also help engage our minds. Just look at London cab drivers who have to memorise 25,000 streets and 20,000 landmarks before they can achieve their cabbie licence. Studies have revealed that the average London cabbie has a larger-than-average hippocampus (a part of the brain responsible for memory).

4. Feed your brain

Feed your brain

What we eat can have a significant impact on mood and memory. Following a healthy diet has been found to slow brain ageing by seven and a half years.

For example, broccoli is rich in vitamin K, which has been linked to improved memory in older adults. Studies also show dark chocolate can stimulate blood flow to the brain and encourage blood vessel and neuron growth in areas involved in learning and memory.

In contrast, research shows that refined carbohydrates, sugary drinks, alcohol, and trans fats can affect brain function by disrupting communication between cells and causing inflammation.

As a result, it’s important to eat a healthy, balanced diet with as many whole foods as possible. For inspiration, check out our articles: 10 foods to boost your brain health and 12 foods that can help reduce the risk of dementia.

Note: Because food intolerances can cause brain fog, you should speak to your doctor if you think that particular foods or drinks don’t agree with you. They may refer you to a specialist for an allergy test.

5. Try new things

Developing new brain cells is important because they not only help us learn but can also improve reaction times and attention to detail. They do this when they connect with other brain cells to form new learning pathways.

Stepping outside of your comfort zone and trying different things is one way to encourage this. For example, learning to knit, picking up a new language, trying a sport, or developing your baking skills.

You can find many more new ideas to try in our article: 18 ways to step outside of your comfort zone.

Another way to create new learning pathways and sharpen your thinking is to complete your usual tasks differently. For example, you could write with the opposite hand, take a new route to the shops, or mix up your daily routine. This can take your brain off autopilot, so it has to pay attention and work hard to develop new learning pathways.

6. Stay social

A growing body of research supports the link between social activities and sharper thinking.

More studies are needed to understand why this is, but according to Age UK, meaningful interactions with others may provide a buffer against factors particularly harmful to brain function, such as stress. Being with others can also stimulate attention and memory and strengthen neurological pathways.

However, socialising can become trickier with age. If this sounds familiar, try to remember there are plenty of others in the same boat, and it’s never too late to make new connections.

Our articles, 12 ways to make new friends and 9 different ways to meet new people, have plenty of tips that’ll hopefully help you meet like-minded people. 

7. Take breaks

Take breaks

Many of us forget to take breaks, but overworking can lead to stress and fatigue, which can cause or worsen brain fog.

For example, say you’ve got a project due at work that you’ve already put hours into but is still incomplete. Perhaps you’ve worked on it long enough that you’re struggling to focus, are overcorrecting your mistakes, and are losing sight of whether it even makes sense, but feel compelled to carry on.

In situations like this, we rarely regain focus without stepping back, so try to take regular breaks – not only from your work but also from other aspects of life that may drain your energy. To be our most productive selves, we need sensory rest, social rest, and creative rest, as well as sleep.

For example, if you’ve been doing something that’s mentally taxing, it’s important that your break includes mental rest and doesn’t involve simply switching to another similar task. Instead, you could go for a walk or do something that occupies your hands but not your mind. To learn more, check out our article: The 7 types of rest you need to be your most productive self.

If you find it challenging to take breaks, try making time in your diary as you would with anything else. This quote from Healthline is great at explaining the importance of taking breaks…

“Think about driving through a heavy downpour: If you can’t see the road or concentrate over the sound of hail hitting your windshield, it’s wise to just pull over until things calm down. Same goes for trying to get things done when your brain’s feeling foggy.”

8. Incorporate regular exercise into your routine

Incorporate regular exercise into your routine

Because our minds and bodies are intimately connected, the physical activity we do can affect brain function. Aside from the mood-boosting benefits that many of us are familiar with, exercise benefits brain health in various ways.

Studies suggest it can significantly improve people’s creative thinking, problem-solving abilities, and memory. It’s also been shown to clear brain fog and improve concentration.

For example, this study revealed that the attention span of pupils was improved when lessons were broken up with a 20-minute aerobics session.

Another study found that regular exercise may improve thinking skills in people with cognitive impairment. Participants who practised aerobics three times a week had improved planning abilities.

For ideas on incorporating more exercise into your routine, check out our fitness and exercise section. Here, you’ll find information on everything from how to increase your step count to playing pickleball.

9. Explore ways to manage stress and anxiety

Hormones such as cortisol, adrenaline, and norepinephrine are released when we’re stressed or anxious. When they’re present for too long, these hormones can overwhelm and exhaust the brain, making it more difficult to think clearly. Unfortunately, as brain fog increases, stress can increase as well, and the cycle continues.

To avoid getting caught in this loop and help clear a cloudy mind, it’s worth exploring ways to manage stress and anxiety. Learning to focus on the present by becoming more aware of your thoughts, feelings, and surroundings is an effective way to do this. It can prevent rumination over the past and future and provide a sense of calm and control.

Challenging negative thoughts and finding ways to help others can also help with stress and anxiety

10. Get plenty of fresh air and stay hydrated

Get plenty of fresh air and stay hydrated

Fresh air and water play key roles in brain health, yet they’re often overlooked.

Oxygen is essential for healthy brain function. Twenty percent of the air we breathe is used by our brain, so our minds can feel sluggish if we don’t get enough.

For some fun outdoor ideas, you might like to read our article: 32 ways to connect with nature and feel inspired. From birdwatching to outdoor yoga, there’ll hopefully be an activity for you.

The NHS recommends drinking six to eight glasses of fluid a day to keep our brains functioning properly. Our brains are made up of 75% water, which means that even slight dehydration can impact brain function.

Check out our article, 10 tips for staying hydrated and why it’s important, for more information.

Final thoughts…

Brain fog can occur for many reasons – including stress, a lack of sleep, having an underlying health condition, and/or going through menopause. And though it can be frustrating and disruptive to daily life, we hope some of the tips in this article will be useful.

It’s also important to remember you’re not alone. Brain fog is something many of us experience at one time or another. However, if it’s affecting your quality of life or doesn’t go away, it’s important to speak to your GP.

Brain fog isn’t always easily understood by those who haven’t suffered from it, but through open communication, we can continue breaking the stigma around mental health and shine a light on the information and support that’s available.

For more tips on looking after your mental health, you might like to visit our healthy mind section.

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